Some are based on inactivated forms of the virus.
In all honesty it was just a joke, though. I don't expect this to ever happen, as there's no money in it 😒
Well yes and no.
It infects cells, but it doesn't reproduce and it doesn't actually damage the cells.
Viruses infect the cells, make them create more viruses, then kill the host cells and proceed to infect even more cells.
And this is an important distinction between the vaccine and the actual virus.
@fribbledom this would be nearly impossible. Basically, because if it spreads, it has to replicate. And every single time that virus replicates, it has a small chance of becoming malignant instead (esp because RNA has terrible stability compared to DNA, and even DNA mutation = cancer). An exponential chance of having happened, with each viral generation. And as soon as that happens, the malignant version is *better* at reproducing itself and spreading than the vaccine version, because... it doesn’t care about keeping you safe. And now you just have another (very expensive) deadly virus.
@fribbledom and okay, say that that’s an exaggeration and instead of basing the vaccine on a dangerous virus like a coronavirus, it’s a very gentle virus like attenuated cowpox, only giving most people a bad cold (and killing some small percentage; any replicating virus will be severe for an immunosuppressed person). Since it’s not based on the more dangerous virus, the part of the vaccine-virus that is providing the recognition to the immune system isn’t itself critical to said virus’ survival, and so it will get rid of it. Viruses don’t keep bits that aren’t positive adaptations for long; RNA replication is too volatile.
@fribbledom (sarcasm) No money in that. You wouldn't want your medicine to heal people for free 😉 we are not communists.
@simon I kinda to the point that commercial funding is necessary for healthcare research.
Especially for covid where:
1) companies got huge grants from governments to start research;
2) they don't bear the long term risks of the vaccine;
Why can't we lift their patents and allow anybody to synthesise the vaccines (especially in the developing word).
Apart from the COVID case its a question whether can we finance vaccine research via public money.
@simon maybe let me rephrase the argument from the gird post. If we had magical possibility to make a self replicating vaccine, the such a product would not make any sense in modern commercial world. As you could send it only once (and then it would spread). And that was the sarcasm.
Apparently Hungary and Russia are working on joint production of Sputnik so there is a possibility to ramp up production (it's a different technology and maybe the governments are lying though).
@simon Also I still believe that situation where the public paus for development of the vaccine, then pays commercial price for it, and bears full risk of long term side effect is well situation good for shareholders but bad deal for the public.
@fribbledom The live polio vaccine was contagious :)
It was part of the whole strategy when they lacked the systems and tools to actually track and assess coverage, they would make assumptions about how many people would be vaccinated by each dose in a particular area. Particularly in areas of dense habitation or poor sanitation, basically the places where polio spread the fastest anyway.
@seachaint @fribbledom s/was/is/ there are still places using it and where its spread is a significant cause of polio. ex. https://www.scmp.com/news/world/africa/article/3099946/polio-outbreak-sudan-caused-live-virus-oral-vaccine-world-health
@fribbledom movie answer is also book answer: see “I Am Legend”. (Mutates unexpectedly causing other issues.)
Science answer: allergic reactions if supported by the method of transmission.
@fribbledom You joke, but we can in theory change the environment to increase evolutionary pressure on diseases to be less lethal: https://www.ted.com/talks/paul_ewald_can_we_domesticate_germs
Server run by the main developers of the project It is not focused on any particular niche interest - everyone is welcome as long as you follow our code of conduct!