Kingdom Come: Deliverance looks to be a big, complicated role-playing game in a setting just to the side of what is typical for that genre. It's also very system-driven and reacts to the player's actions so that it "often feels like an immersive sim masquerading as an RPG."
TBH, I’ve dreamt of having a game like this, but set in the fractious Spanish occupation of the Potosí silver mining area.
"Kingdom Come is an RPG without the dungeons or dragons. There are no goblins, enchanted swords, or mages. You’ll never cast a spell, slay a vampire, or fulfil an ancient prophecy. And there’s something refreshing about how it trades these familiar fantasy tropes for something more understated and realistic." 😀