How to run Mastodon as an independent web app on Windows:
1. Open Chrome
2. “More tools” -> “Add to desktop ...”
3. Right-click the desktop shortcut created
4. Click “pin to taskbar”
You now have your own Mastodon app you can open and close independent of Chrome. https://mastodon.social/media/ojS8wMktlczAGZLsLlA
The same works very well for YouTube and Twitch btw.
You should be able to do the same with Fluid.app [fluidapp.com] on macOS.
I mean, you could do the same with Chrome on macOS, but the browser tends to eat MacBook batteries for breakfast, so you’ll probably want to run it in Safari.