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#hippocampus

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“The posterior hippocampi of taxi drivers were significantly larger relative to those of control subjects,” she wrote in Proceedings of the National Academy of Sciences. And the size, she found, correlated with the length of a cabby’s career: The longer the cabby had driven, the bigger the hippocampus.

nytimes.com/2025/02/14/science

Eleanor Maguire in an undated photo. “She changed our understanding of memory,” said Chris Frith, an emeritus professor of neuropsychology at University College London.
The New York Times · Eleanor Maguire, Memory Expert Who Studied London Cabbies, Dies at 54By Michael S. Rosenwald

"In mice, here we reveal a non-pyramidal excitatory neuron type — the “ovoid” neuron — that is spatially adjacent to subiculum pyramidal cells but differs in gene expression, electrophysiology, morphology, and connectivity. Functionally, novel object encounters drive sustained ovoid neuron activity, whereas familiar objects fail to drive activity even months after single-trial learning."

nature.com/articles/s41467-025

NatureAtypical hippocampal excitatory neurons express and govern object memory - Nature CommunicationsPyramidal cells are classically thought to comprise the excitatory output of the subiculum. Here, the authors show the existence of “ovoid cells”, excitatory subiculum neurons with specialized gene expression, morphology, projections, and function.