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#immunity

7 posts7 participants0 posts today

Immune amnesia: Why even mild measles infections can lead to serious disease later

Getting measles doesn’t confer benefits on the immune system — in fact, it’s just the opposite.
Even a mild case of measles destroys the memory cells that confer resistance on bugs the patient has previously fought, in what doctors call “immune amnesia.”
A measles outbreak has infected nearly 500 people in 19 states, including California. Vaccinations prevent both the measles and the subsequent loss of immune protections.

It's true. It's happened to me in the time before a measles vaccine. I got very ill...Hospitalized. I also went through a series of very painful gamma globulin shots to get some immunity built back up. Don't let this happen to your child...or you.

#measles #immunity #immuneamnesia

latimes.com/science/story/2025

A baby hospitalized with measles.
Los Angeles Times · Measles erases immunological memoryBy Corinne Purtill

Human defense peptides

Guðmundur H Guðmundsson

Host defense peptide expression improve the epithelial barrier

"Our studies on innate immunity with emphasis on front line defenses have unfolded key components in our innate immunity. Among the components is the sole human cathelicidin containing the host defense peptide LL-37"

It all started with a moth

#immunity #ll37 #cathelicidin #evolution #Iceland #biology #UniversityIceland

english.hi.is/bmc-seminar-host

Obesity Cripples Anti-Bacterial Immunity: It cripples your white blood cells, the neutrophils, that kill bacteria. #obesity #fattydiet #bacteria #immunity #neutrophils #phagocytosis
instagram.com/reel/DH9NiUTtOcR

InstagramHoward G. Smith MD, AM on Instagram: "Obesity Cripples Anti-Bacterial Immunity Obesity due to consistent ingestion of a high-fat diet limits that ability of your white blood cells to effectively fight bacterial infections. Pediatric researchers at the University of Michigan studied this phenomenon in a mouse model and now report their findings in The Journal of Immunology. Obesity was induced with a sustained, 16 week, high fat diet. The bacteria-fighting lymphocytes, so-called neutrophils, generated by these obese mice produce diminished bactericidal secretions, are less capable of ingesting or phagocytosing these pathogens, and lack normal regenerative capabilities in comparison to those neutrophils found in control mice with normal weights. This study adds yet another reason for obese persons to cut out fats in their diets and normalize their body weights. Besides reducing the risk of heart attacks and alleviating the burdens their joints and backs must bear, they will repower their immune systems to protect them against serious and often life-threatening bacterial disease. https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf024/8081674 #obesity #fattydiet #bacteria #immunity #neutrophils #phagocytosis"0 likes, 0 comments - drhowardsmithreports on April 2, 2025: "Obesity Cripples Anti-Bacterial Immunity Obesity due to consistent ingestion of a high-fat diet limits that ability of your white blood cells to effectively fight bacterial infections. Pediatric researchers at the University of Michigan studied this phenomenon in a mouse model and now report their findings in The Journal of Immunology. Obesity was induced with a sustained, 16 week, high fat diet. The bacteria-fighting lymphocytes, so-called neutrophils, generated by these obese mice produce diminished bactericidal secretions, are less capable of ingesting or phagocytosing these pathogens, and lack normal regenerative capabilities in comparison to those neutrophils found in control mice with normal weights. This study adds yet another reason for obese persons to cut out fats in their diets and normalize their body weights. Besides reducing the risk of heart attacks and alleviating the burdens their joints and backs must bear, they will repower their immune systems to protect them against serious and often life-threatening bacterial disease. https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf024/8081674 #obesity #fattydiet #bacteria #immunity #neutrophils #phagocytosis".
Continued thread

#DOJ Exhibit 1:

“I, C.Salvatore D'Alessio, Jr, Dir, Torts Branch, Civil Division, US DOJ,…hereby certify that I have read the Amended Complaint in this action. On the basis of the information now available w/respect to the claims set forth therein, I find that Donald J. Trump was acting within the scope of federal office or employment at the time of the incidents out of which the plaintiffs' claims arose.”

Bullshit

#law #BlassingameVTrump #SCOTUS #immunity #Trump #Jan6
storage.courtlistener.com/reca

Continued thread

#Trump is currently trying to use the shield of presidential #immunity to snuff out these 8 consolidated lawsuits. Opposing lawyers countered in Feb with a 55-pg court filing that was supported by 186 exhibits.

3 of those apparently involve #DanScavino, who’s now trying to keep them from going public.

Encouraging: "WH press secretary Karoline Leavitt just said the administration is not planning any further deportation flights to El Salvador."
-R Sollenberg

"Karoline Leavett was just humiliated on LIVE TV:

Leavitt: “The judge is a Democratic activist judge appointed by Obama.”

Reporter: “He was originally appointed by GW Bush.”
-Call to Activism

Trump must realize that SC CJ Roberts isn't going to give him carte blanche. He doesn't have absolute #immunity.

📰 "A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity"
biorxiv.org/content/10.1101/20
#Drosophila #Immunity #Adult
#Toll

bioRxiv · A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identityChromatin modulators, like Polycomb group proteins, are key epigenetic regulators of gene expression and are frequently mutated in cancers. In adult stem cells, epigenetic regulation maintains their identity and controls their differentiation during homeostasis or aging, but its direct role in tumorigenesis remains unclear. This work explores the function of Polycomb Repressive Complex 1 (PRC1) in adult Drosophila intestinal stem cells (ISCs). Disrupting core PRC1 components in ISCs induces the formation of small cell clusters devoid of intestinal markers, a novel phenotype linked to premature mortality under stress. Notably, transient PRC1 loss is sufficient for cluster formation. These clusters overproliferate and exhibit immortality in serial transplantations, leading to their designation as tumor-initiating intestinal cells (TIICs). While JAK/STAT signaling promotes TIIC formation, the TOLL/IMD immune pathways restrict their expansion independently of cell death. Altogether, our results highlight PRC1 as an epigenetic tumor suppressor in adult intestinal stem cells. ### Competing Interest Statement The authors have declared no competing interest.

"Taxpayers were not made fully whole for the millions of dollars of repairs & cleanup from the damage of the Capitol Insurrection.

After the Trump pardons of rioters, defendants are now seeking to get reimbursed from taxpayers for their court-ordered restitution payments"
-S MacFarland

Republican Senators & Reps are complicit, they're allowing Trump to do anything he pleases. What will change their minds? Will #SCOTUS continue to🚨grant #Trump absolute #immunity?

Climate litigation - Environmental groups sound new alarm as fossil fuel lobby pushes for immunity theguardian.com/us-news/2025/m

Nearly 200 groups urge Congress to reject fossil fuel industry immunity efforts, fearing long-term damage to climate lawsuits

“Lawmakers must decisively reject any attempt by the fossil fuel industry to evade accountability and ensure both justice today and the right of future generations to hold polluters responsible for decades of deception,” said the missive, which is addressed to the House minority leader, Hakeem Jeffries, and Senate minority leader, Chuck Schumer.

Fossil fuel companies have vied for such a get-out-of-jail-free card for years.

The Guardian · Environmental groups sound new alarm as fossil fuel lobby pushes for immunityBy Dharna Noor