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Mastodon: AboutGet the appKeyboard shortcutsView source codev4.4.0-nightly.2025-04-01

#n1

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Public
Giuseppe Michieli

A Computationally Optimized Broadly Reactive #Hemagglutinin and #Neuraminidase #Vaccine Boosts #Antibody-Secreting Cells and Induces a Robust #Serological Response, Preventing #Lung #Damage in a Pre-Immune #Model pubmed.ncbi.nlm.nih.gov/390663

... the combination of #H2, #H5, #H7, #N1, and #N2 #COBRA #antigens presents a potential for the formulation of a universal influenza virus vaccine.

PubMedA Computationally Optimized Broadly Reactive Hemagglutinin and Neuraminidase Vaccine Boosts Antibody-Secreting Cells and Induces a Robust Serological Response, Preventing Lung Damage in a Pre-Immune Model - PubMedThe hemagglutinin (HA) and neuraminidase (NA) surface proteins are the primary and secondary immune targets for most influenza vaccines. In this study, H2, H5, H7, N1, and N2 antigens designed by the computationally optimized broadly reactive antigen (COBRA) methodology were incorporated into an adj …
Continued thread
Public *
Ghostsigns (Sam Roberts)

Thank you to everyone that contributed to this discussion, which has corrected and deepened our understanding of this ghost sign: Nazalia it is!

I have written this up for the record here on the Ghostsigns blog: ghostsigns.co.uk/2024/07/x-doe

Thanks again @RoyReed @mass_driver @RayNewman @freetobeme @6b6279

X Doesn’t Mark the Spot: Revisiting an Islington Ghost Sign| Ghostsigns | Correcting the record for the Popham Street ghost sign previously thought to advertise X-Zalia, but now known to be for Nazalia. Photo: Roy Reed. · X Doesn’t Mark the Spot: Revisiting an Islington Ghost Sign |Correcting the record for the Popham Street ghost sign previously thought to advertise X-Zalia, but now known to be for Nazalia. Photo: Roy Reed.
#ghostsigns#islington#london
Public *
Ghostsigns (Sam Roberts)

What's the missing word on this London ghost sign? @RoyReed recently got some better pictures than mine from the book, but we're stuck on the last line.

"___ Simple & Inexpensive"
[Rest in alt text]

I think I can see one of C/G/O as the first letter, and that it ends with an 'm' or 'rn', but none of the permutations are suggesting any fitting words.

Please reply with answers/guesses, and boost to get more eyes on it...

Brick wall with a stucco panel set within a scalloped molded border. There is a fading painted sign on the panel which is more visible on the rightmost two thirds due to the leftmost third having a coat of blue paint over it. The visible lettering reads: X-Zalia Day & Night Cure for Catarrh & Colds in the Head Prevents Influenza [...] Simple & Inexpensive
Closer crop into the sign from the previous photo showing the portion with the missing word on the last line.
#ghostsigns#lettering#islington
Public
Giuseppe Michieli

#Development and characterization of an #antibody that recognizes #influenza virus #N1 #neuraminidases pubmed.ncbi.nlm.nih.gov/387230

However, further validation is necessary to confirm whether FNA1 mAb is indeed a good inhibitor against NA for application against H1N1 and H5N1 viruses.

PubMedDevelopment and characterization of an antibody that recognizes influenza virus N1 neuraminidases - PubMedInfluenza A viruses (IAVs) continue to pose a huge threat to public health, and their prevention and treatment remain major international issues. Neuraminidase (NA) is the second most abundant surface glycoprotein on influenza viruses, and antibodies to NA have been shown to be effective against inf …
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