The highest quality #CharityShopClassics #Parpage for you now Taken from Cassette - Ray Davis & His Button Down Brass - It’s Not Unusual #FunkyTrumpet Dedicated to @vinylcarbooty.bsky.social #Parp #BaBaBaa

That latest update to Friday's yellow wind warning is a bit disturbing. Going to have to strap a load of stuff down before then.
#GlasgowWind #Parp

Blimey, Riley! number 80

Some great work from an A/Prof Liz Caldon on predicting #PARP inhibition response in #cancer
https://youtu.be/_Kej9mjRxzw?si=QlN_5CLE7YlbfO1H

RT by @Arlukowicz: Mamy gigantyczną aferę na 2 miliardy - analogiczną do sprawy w NCBiR. #PARP
https://wiadomosci.wp.pl/michal-szczerba-o-nowej-aferze-pis-gigantyczne-nieprawidlowosci-6958035221223041v

: https://nitter.cz/MichalSzczerba/status/1719269317617803582#m

[2023-10-31 08:25 UTC]

Unrepaired base excision repair #BER intermediates trigger #replication fork collapse and #PARP inhibitor sensitivity when present in template DNA strands, rather than in nascent strands behind forks – find Keith Caldecott, Steve Jackson, Nicolas Hoch and colleagues

https://www.embopress.org/doi/full/10.15252/embj.2022113190

RT PARP
Znajdź dofinansowanie dla swojej firmy. Sprawdź aktualną ofertę konkursów w #PARP
Obecnie trwa nabór do kilkunastu konkursów, które stanowią unikalną szansę dla przedsiębiorców na zdobycie wsparcia finansowego w ramach #FunduszeUE.
https://www.parp.gov.pl/component/content/article/84452:znajdz-dofinansowanie-dla-swojej-firmy-aktualna-oferta-konkursow-parp https://t.co/7JYeIB0JzP

: https://n.respublicae.eu/parpgovpl/status/1672162951795548166

It's a long, drawn-out process to get information from #WMATA via the #PARP process...

When stressed or infected, plants modify proteins by #ADP-ribosylation. But how are these signal interpreted? New data from the Kangasjärvi lab shows that transcriptional co-regulator RCD1 binds to poly-ADP-ribose chains and might act as a PAR 'reader'. #PTM #PARP #plantscience https://t.ly/HHyP

#NowPlaying on #CharityShopClassics on @ALLFM... Please Please Me tijuana style! #parp

Listen: 96.9 in Mcr, https://player.broadcast.radio/allfm or on your streaming app/device

Did anyone else from team #ADPribosylation #PARP arrive on mastodon yet??
Following them on the birdapp is the only reason I haven't deleted my account yet...

Discussion on #PARP resistance and multiple mechanisms that can lead to this challenging problem in the clinic.

#POLtheta inhibitors may be able to overcome this resistance alone & w/PARP.

levels of #POLtheta and certain mutations predict sensitivity

#SABCS22 @OncoAlert@twitter.com

Dr Eileen O’Reilly at #MSK ordered germline & somatic testing soon after Jay’s diagnosis with #PancreaticCancer, years before it was an #ASCO guideline. He was found to have a gBRCA1 mutation - targetable by #PARP inhibitor #olaparib - allowing a welcome chemo break. So grateful for the eight years we had post-diagnosis.
#PancreasCancer
#BRCA

#introduction
Hi, I am Matthew and currently work on #ovarian #cancer with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to #PARP inhibitors.
Currently this is involving lots of #FunctionalGenomics with #MAVE assays and #DMS (#DeepMutationalScanning) to dissect protein complex interactions with inhibitors.
I mainly do #ComputationalBiology and supervise a team that does the wet work.
Trying to create a focused work engagement in this account