whitequark @whitequark@mastodon.social
http://whitequark.org · http://llvm.moe · http://powerlinesinanime.tumblr.com · working on quantum computers for a living · she · #nobot
USB over USB
alcohol addiction linked to variation of GAT3, GABA reuptake pump, in amygdala
http://science.sciencemag.org/content/360/6395/1321
"Observing the backside of ICs, the system captures extremly weak photo-emissions from switching transistors and relates them to code running in the chip [...] recover the full AES secret key [...]" https://www.researchgate.net/publication/257803918_Simple_Photonic_Emission_Analysis_of_AES
boy, the immune system is impressive, i think, before remembering allergies (it still is tho) https://doi.org/10.1073/pnas.1300752110
Hm, apparently #letsencrypt now provides mor than 50% of the web certificates.
On one hand: FUCKING AWESOME.
On the other: Shit. They're getting very powerful and we are centralizing our trust. I think we could reallu use 2-3 new orgs like Letsencrypt, with similar technology and mission statement, but entirely independent.
Are there any out there yet?
"Salsify: Low-Latency Network Video through Tighter Integration between a Video Codec and a Transport Protocol.", pretty interesting approach https://snr.stanford.edu/salsify/#paper
Update on the situation, it's improved but I still need help: https://matildah.github.io/posts/2018-04-16-update.html
if you know of someone vaguely near Los Angeles who has a room they can rent to me, please let me know!
this quote from Bunnie Huang is, i think, probably the best justification for proactive correction of biases i've seen
Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the Mouse
http://journals.sagepub.com/doi/10.1038/jcbfm.2008.8
Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
https://www.nature.com/articles/nm903
Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease
http://www.jbc.org/content/279/31/32345
"Treatment of the FF group with low dose 2,4-dinitrophenol to increase energy expenditure abrogated the development of fatty liver, hepatic insulin resistance, activation of PKC-ϵ and JNK1, and defects in insulin signaling."
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats
http://science.sciencemag.org/content/347/6227/1253
Insulin resistance is a cellular antioxidant defense mechanism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764908/
"In particular, insulin resistance was rapidly reversible upon exposure to agents that act as mitochondrial uncouplers, ETC inhibitors, or mitochondrial superoxide dismutase (MnSOD) mimetics."
Metformin directly acts on mitochondria to alter cellular bioenergetics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147388/
"We show that metformin decreases mitochondrial respiration, causing an increase in the fraction of mitochondrial respiration devoted to uncoupling reactions."
Novel neuroprotective, neuritogenic and anti‐amyloidogenic properties of 2,4‐dinitrophenol: The gentle face of Janus
https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1080/15216540600702198
Mitochondrial uncoupler 2, 4-dinitrophenol (DNP) counters radiation induced cell death by stimulating anti-oxidant defence system
https://inis.iaea.org/search/search.aspx?orig_q=RN:46095505
Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis
https://www.hindawi.com/journals/omcl/2017/7180632/abs/
Recruitment of the Auditory
Cortex in Congenitally Deaf
Cats by Long-Term Cochlear
Electrostimulation
http://sci-hub.hk/10.1126/science.285.5434.1729
we're able to restore hearing in congenitally deaf cats (white fur, blue eyes, etc) with cochlear implants! the organ of Corti (sensory organ of hearing) is degenerate at birth, but auditory areas of the brain are not, and can be recovered if stimulated; otherwise, it'll degenerate too.
Derek's summary of the paper http://blogs.sciencemag.org/pipeline/archives/2018/04/10/21st-century-enzymes
