Giuseppe Michieli<p>Identification and characterization of a broadly neutralizing and protective <a href="https://mstdn.science/tags/nanobody" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>nanobody</span></a> against the <a href="https://mstdn.science/tags/HA1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>HA1</span></a> domain of <a href="https://mstdn.science/tags/H5" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>H5</span></a> avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>influenza</span></a> virus <a href="https://mstdn.science/tags/hemagglutinin" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hemagglutinin</span></a>, <a href="https://etidiohnew.blogspot.com/2025/04/identification-and-characterization-of.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">etidiohnew.blogspot.com/2025/0</span><span class="invisible">4/identification-and-characterization-of.html</span></a></p>
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#ha1
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Giuseppe Michieli<p>Large-scale computational <a href="https://mstdn.science/tags/modelling" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>modelling</span></a> of <a href="https://mstdn.science/tags/H5" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>H5</span></a> <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>influenza</span></a> <a href="https://mstdn.science/tags/variants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>variants</span></a> against <a href="https://mstdn.science/tags/HA1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>HA1</span></a>-neutralising <a href="https://mstdn.science/tags/antibodies" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>antibodies</span></a>, <a href="https://etidiohnew.blogspot.com/2025/03/large-scale-computational-modelling-of.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">etidiohnew.blogspot.com/2025/0</span><span class="invisible">3/large-scale-computational-modelling-of.html</span></a></p>
Giuseppe Michieli<p>Large-Scale Computational <a href="https://mstdn.science/tags/Modeling" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Modeling</span></a> of <a href="https://mstdn.science/tags/H5" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>H5</span></a> <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Influenza</span></a> <a href="https://mstdn.science/tags/Variants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Variants</span></a> Against <a href="https://mstdn.science/tags/HA1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>HA1</span></a>-Neutralizing <a href="https://mstdn.science/tags/Antibodies" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Antibodies</span></a></p><p>Source: BioRxIV, AbstractThe United States Department of Agriculture has recently released reports that show samples from 2022-2024 of highly pathogenic avian influenza (H5N1) have been detected in mammals and birds. To date, the United States Centers for Disease Control reports that there have been 27 humans infected with H5N1 in 2024. The broader potential impact on…</p><p><a href="https://etidioh.wordpress.com/2024/11/09/large-scale-computational-modeling-of-h5-influenza-variants-against-ha1-neutralizing-antibodies/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">etidioh.wordpress.com/2024/11/</span><span class="invisible">09/large-scale-computational-modeling-of-h5-influenza-variants-against-ha1-neutralizing-antibodies/</span></a></p>
Giuseppe Michieli<p>Large-Scale Computational <a href="https://mstdn.science/tags/Modeling" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Modeling</span></a> of <a href="https://mstdn.science/tags/H5" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>H5</span></a> <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Influenza</span></a> <a href="https://mstdn.science/tags/Variants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Variants</span></a> Against <a href="https://mstdn.science/tags/HA1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>HA1</span></a>-Neutralizing <a href="https://mstdn.science/tags/Antibodies" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Antibodies</span></a>, BioRxIV: <a href="https://www.biorxiv.org/content/10.1101/2024.07.14.603367v3" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.07.14.603367v3</span></a> </p><p>This study shows a trend of weakening of the binding affinity of existing antibodies against H5 isolates over time, indicating that the <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>H5N1</span></a> virus is evolving immune escape of our medical defenses.</p>
Giuseppe Michieli<p>Large-Scale Computational <a href="https://mstdn.science/tags/Modeling" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Modeling</span></a> of <a href="https://mstdn.science/tags/H5" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>H5</span></a> <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Influenza</span></a> <a href="https://mstdn.science/tags/Variants" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Variants</span></a> Against <a href="https://mstdn.science/tags/HA1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>HA1</span></a>-Neutralizing <a href="https://mstdn.science/tags/Antibodies" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Antibodies</span></a>, BioRxIV: <a href="https://www.biorxiv.org/content/10.1101/2024.07.14.603367v2" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.07.14.603367v2</span></a> </p><p>This study shows a <a href="https://mstdn.science/tags/trend" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>trend</span></a> of weakening binding <a href="https://mstdn.science/tags/affinity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>affinity</span></a> of existing antibodies against H5 isolates over time, indicating that the <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>H5N1</span></a> virus may be evolving immune <a href="https://mstdn.science/tags/escape" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>escape</span></a> of our medical defenses.</p>
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