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#Pharmacometric

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Justin Wilkins<p><span class="h-card"><a href="https://mastodon.ie/@ConorMahood" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>ConorMahood</span></a></span> <span class="h-card"><a href="https://mastodon.online/@RolloTreadway" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>RolloTreadway</span></a></span> I’m a pharmacometrician. I build mathematical models for how drugs are processed in the body and how they work to treat illness. </p><p>In <a href="https://fosstodon.org/tags/pharmacometric" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>pharmacometric</span></a> models, drugs moving through complex biological systems are often represented by interlinked “compartments” - see <a href="https://journals.sagepub.com/doi/pdf/10.1177/019262339502300203" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">journals.sagepub.com/doi/pdf/1</span><span class="invisible">0.1177/019262339502300203</span></a> for a massively more technical explanation! </p><p>TL;DR we use math to describe and predict how drugs work.</p>
Justin Wilkins<p>We can use <a href="https://fosstodon.org/tags/Pharmacometric" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Pharmacometric</span></a> models like these to <a href="https://fosstodon.org/tags/Simulate" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Simulate</span></a> clinical trials, dose regimens and so on, in silico, so that we can predict what will happen when we actually give a drug to a human, and whether the design we have proposed for our clinical trial will actually work when we run it.</p>