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#dendrites

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`In this work, we investigated the of layer 2 and 3 (L2/3) pyramidal of the human cerebral cortex ex vivo. In these neurons, we discovered a class of -mediated dendritic action potentials (dCaAPs) whose waveform and effects on output have not been previously described. In contrast to typical all-or-none action potentials, dCaAPs were graded; their amplitudes were maximal for threshold-level stimuli but dampened for stronger stimuli`

science.org/doi/10.1126/scienc

( ) are amongst the most complex cell types in our body. They achieve this complexity during development by extending ramified branches called and and establishing thousands of synapses to form intricate networks.

sflorg.com/2024/04/ns04082401.

www.sflorg.comFueling nerve cell function and plasticityHow mitochondria control tissue rejuvenation and synaptic plasticity in the adult mouse brain

"Here we combine cable and renewal theory to describe how input fluctuations shape the response of neuronal ensembles with active . We found that dendritic input readily and potently controls interspike interval dispersion. This phenomenon can be understood by considering that display three fundamental operating regimes: one mean-driven regime and two fluctuation-driven regimes."

nature.com/articles/s43588-023

NatureDendritic excitability controls overdispersion - Nature Computational ScienceA mathematical framework that allows computing the input–output function of neurons with active dendrites reveals how dendrites readily and potently control the response variability, a result that is experimentally confirmed.

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a research assistant who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501807) at the Drexel Human Resources website. careers.drexel.edu/en-us/job/5

If you have any questions, please email me at kt469@drexel.edu.
#autism #ASD #therapy #DrugDiscovery #ResearchAssistant #ResearchAssistantJob #AcademicJob #LabTechnician #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a postdoctoral researcher who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501741) at the Drexel Human Resources website. careers.drexel.edu/en-us/job/5

If you have any questions, please email me at kt469@drexel.edu.

#autism#ASD#therapy

"Knock out of Noelins1-3 profoundly reduced AMPARs in synapses onto excitatory and inhibitory (inter)neurons, decreased their density and clustering in , and abolished activity-dependent plasticity. Our results uncover an endogenous mechanism for anchoring of AMPARs and establish Noelin-organized networks as versatile determinants of constitutive and context-dependent ."

cell.com/neuron/fulltext/S0896