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Augie Ray

A five-minute update 🧵:

- COVID is still rising in the US, but it appears to be doing so at a slower rate. It is very uneven across the nation, however. I predicted six weeks ago this surge would be worst in the South due to heat and time indoors in air conditioning. Currently, the 10 counties with the highest COVID hospital admission rate are in Alabama, Mississippi, Georgia, Texas, and Louisiana. The next ten are almost all in the Plains and Texas. usnews.com/news/health-news/ar

- This doesn't mean we're out of the woods with this surge and that it's safe to ignore COVID (as almost everyone is.) For example, here in Wisconsin, COVID in wastewater is still rising at an alarming rate--up 80% in two weeks. Check whatever data is available in your neck of the woods, please. dhs.wisconsin.gov/covid-19/was

- While the end of this surge may be a couple of weeks off nationally, please appreciate the risks are high and still rising. The CDC data on positive rate is at the third-highest level of the pandemic, and a respected immunologist estimates one of every 53 Americans is infected with currently. And with the number of new variants, it's possible the end of this surge will just be a pause before the fall wave ignites in around six weeks. covid.cdc.gov/covid-data-track

Centers for Disease Control and Prevention · COVID Data TrackerBy CDC

- This is some mixed news about the B.2.86 variant that has been creating headlines lately. It continues to be found in more states and nations, suggesting widespread transmission. But, a study has found this variant may have LOWER infectivity while defeating a huge amount of immunity protection. This variant may not create a giant new surge, but it is a risk to people who think they're immune (and the new fall vaccine may not be as effective at preventing infections). original.newsbreak.com/@shin-5

NewsBreak OriginalPirola/BA.2.86 Variant Is Actually Less Infectious Than Eris/EG.5 and XBB.1.5: New Data | Shin | NewsBreak OriginalThe unfolding saga of the COVID-19 pandemic has brought another unexpected chapter. The buzzworthy "Pirola" BA.2.86 variant, previously believed to be the next grim headline in our battle against the virus, might actually be less threatening than initially anticipated.

- That isn't the end of the story for BA.2.86, however. This variant made a significant evolutionary jump, likely because it mutated within the body of a single chronically ill person. That means natural selection fine-tuned the virus to survive in that one person, but now that's it in the wild and spreading between people, natural selection will push the virus to be more infectious to everyone else.
finance.yahoo.com/news/pirola-

consent.yahoo.comYahooist Teil der Yahoo Markenfamilie

And because we're all so busy pretending COVID is over, we are encouraging a high level of infection and rapid mutation. BA.2.86 is already mutating, and experts are particularly worried about the risk of recombinant variants between B.2.86 and XBB variants causing surges presently. If we reduced infections, we'd slow the rate of mutation of ; instead, our normal behaviors are simply creating high rates of evolution which can (and undoubtedly will) lead to more dangerous COVID variants.

- While it's difficult to prevent any infection, a new study suggests being a little cautious can go a long way to keeping you and those you love safe. The study found that the amount of to which you're exposed matters. People with hybrid immunity (both prior infection and vaccinations) are generally safe if exposure is low to moderate, but are NOT protected from infection if exposure is high. nature.com/articles/d41586-023

www.nature.comCOVID infection risk rises the longer you are exposed — even for vaccinated peopleRigorous evidence shows that significant contact with a person with SARS-CoV-2 is more likely to lead to transmission than a short encounter.

What this means is that a quick trip to an uncrowded store or time spent at an outdoor festival is pretty safe. But, a long period of time indoors in crowded concerts, conferences, classrooms, and bars is not, even for those with hybrid immunity. Ventilation, filtration, density of crowds, length of time, and NPIs like masks all still matter as we approach the fourth anniversary of the continuing pandemic.

- Risks are not equal from one person to another. If you have risk factors (or live with those who do), be more careful. For example, a study found that while the general population saw more COVID-19 deaths during the early period of the pandemic, cancer patients saw deaths peak during the Omicron surge. This isn't because Omicron was more dangerous to cancer patients but that, as we all relaxed cautions, more cancer patients were exposed to a dangerous virus. cidrap.umn.edu/covid-19/cancer

CIDRAPCancer patients saw higher mortality from COVID-19

- Being healthier means you're less likely to suffer consequences but is no guarantee. A new study of elite aquatic athletes at an event last summer found that half were infected at the event. “Most athletes experienced a 'benign' disease course, but reinfections occurred in 13%, and 10% of initial infections led to long .” One in ten elite athletes struggled with Long COVID symptoms, including fatigue (65%) and shortness of breath (48%).
nature.com/articles/s41598-023

NatureRetrospective study of COVID-19 experiences in elite multinational aquatic athletes - Scientific ReportsThis study assessed the experiences of elite aquatic athletes with coronavirus disease 2019 (COVID-19) during the first World Championship conducted without social distancing and an isolation “bubble”. An online questionnaire was completed by 812 athletes (22.7 ± 5.9 years, 467 females) to provide data on demographics, sports activity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates, symptoms, reinfection, vaccination status, and psychological aspects. The answers revealed that 49.4% of athletes had experienced SARS-CoV-2 infection. The infection rates varied significantly across different aquatic sports, with open water swimmers having the lowest (28%) and water polo players (67%) and artistic swimmers (61%) having the highest infection rates (p < 0.0001). The majority reported mild (51%) or moderate (27%) symptoms, while 16% remained asymptomatic. Reinfection occurred in 13%, and 10% of initial infections led to long COVID, with fatigue (65%) and shortness of breath (48%) being the most common long-term symptoms. Significantly, 92% of athletes received at least two vaccine doses and reported a positive vaccination experience (median score of 8 out of 10 for each shot). Mood changes and subjective performance drops significantly correlated with the overall experience scores (rho: 0.617, p < 0.0001, and rho: 0.466, p < 0.0001, respectively). In conclusion, most athletes experienced a benign disease course despite a relatively high infection rate. This study provides valuable insights into the COVID-19 experiences of elite aquatic athletes. The findings emphasize the importance of vaccination initiatives, monitoring psychological well-being and the need to fortify athletes’ resilience in the face of future health challenges.

Another study found that “Left ventricular filling, inflammation, blood coagulation, and hemoglobin appear to be influenced by infection in healthy participants” (mdpi.com/1999-4915/15/8/1623). Please don't pretend you're too young or healthy to worry about the implications of COVID infection.

MDPIEffects of COVID-19 Infection in Healthy Subjects on Cardiac Function and Biomarkers of Oxygen Transport, Blood Coagulation and InflammationBackground: The manifestations, severity, and mortality of COVID-19 are considered to be associated with the changes in various hematological parameters and in immunity. Associations of immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status with cardiac function and hematological and biochemical parameters in apparently health subjects are poorly understood. Methods: The present cross-sectional study included 307 healthy volunteers (24–69 years of age; 44.8 ± 8.6 years; 80.4% men) and was initiated in 2019 before the COVID-19 pandemic. COVID-19 episodes were confirmed by detection of IgG-SARS against SARS-CoV-2 S1 RBD to reveal 70 IgG-SARS-positive and 237 negative participants. Numerous ultrasound characteristics were assessed by echocardiography, and 15 hematological and biochemical parameters were assayed in the blood. Descriptive and comparative analysis was based on the IgG-SARS status of the participants. Results: The left ventricular mass index, mitral ratio of peak early to late diastolic filling velocity or flow velocity across the mitral valve, and deceleration time of early mitral inflow were decreased (p < 0.05) in IgG-SARS-positive participants versus those in IgG-SARS-negative participants according to multivariate logistic regression analysis. Erythrocyte sedimentation rate and platelet count were slightly increased, and blood hemoglobin was decreased in IgG-SARS-positive participants compared with those in IgG-SARS-negative participants. Conclusions: LV filling, inflammation, blood coagulation, and hemoglobin appear to be influenced by COVID-19 infection in healthy participants. Our observations contribute to the definition of vulnerabilities in the apparently healthy subjects with long COVID-19. These vulnerabilities may be more severe in patients with certain chronic diseases.

- Lastly, as I am always warning, the primary risks of
are no longer severe, acute illness and death but that repeated infections are slowly wreaking more havoc within our bodies, leading to disabilities, diminished health, and shortened lifespans. Studies continue to find links between COVID and neurodegenerative diseases (like Alzheimer's), changes in brains and hearts, and possibly cancer. Studies demonstrate the more you get COVID, the higher the risk. nature.com/articles/s41591-022

NatureAcute and postacute sequelae associated with SARS-CoV-2 reinfection - Nature MedicineA new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range of long COVID complications in individuals who have had SARS-CoV-2 compared to those with no reinfection.

A little caution today could prevent illness and disability in the future. The world changed in 2020 when a new virus was introduced. That virus continues to spread and mutate. We are years away from knowing all the implications of repeated infection. If you wear a seatbelt or a bike helmet to reduce the minimal risk from accidents, you should have the same caution about exposing yourself to more COVID infections. A few smarter decisions and a bit more masking might make all the difference!

@augieray
We just got back from a trip to a conference in Tokyo. We wore masks in the airports and during flights and everywhere we went indoors there (and many of the Japanese were wearing also).
We got home and two days later learned that a colleague who attended the same conference tested positive (her roommate did not) Coincidental that we planned to test on that same day. We did, then again two days later and came up negative..
I would say masking can be affective.

@augieray While vaccinations and masking are important, these are individual measures. What is much more important is the rebuilding of our public healthcare systems in countries that have them (that have been victims of years of neo-liberal austerity), and building one in countries like the US that don't have one.

@augieray @leftylabourtech - too bad deniers are the obstacle in keeping the lid on spreading #covid19 - as long as they exist there will be very little chances to create preventive measures nationwide

@BroGle @augieray The neo-liberal way in which the pandemic was largely handled contributed to the creation of the COVID deniers and the anti-vaxxers.

There is no anti-vaxxer movement in Cuba because the state developed it's own COVID-19 vaccines outside of big pharma profiteering. Cuba is one of the most vaccinated countries on the planet.

@augieray Every measure is important but Air quality will make the biggest difference. Every school needs to be pushed to provide clean as virus free as possible air.

@augieray This is something I have been wondering about. (And I am in the camp where I think it's a product of biological research a/k/a bioweapons research.)

@augieray meanwhile the Polish government with their heads in the sand because it's the election year

@augieray FYI almost half were infected *any time prior*, not at that one event. “This study did not involve any SARS-CoV-2 screening or test results from the event.” “We asked about previous SARS-CoV-2 infection(s), including their course and severity. Athletes were asked to identify the time of their infection(s) within six-month periods.”
Athletes with severe current (as of 2022) Long Covid could not have been included, because they wouldn’t have been competing.

@smach Thanks for catching that. Sorry for missing it. That doesn't really change the point I was making that young, healthy people still get Long COVID and suffer the long-term consequences, but I do appreciate the correction.

@augieray I’ve become dangerously dehydrated twice since 2020 because I get abdominal migraines that cause days of vomiting and diarrhea, I had to go to the ER in April 2020, I didn’t want to my doctor kept calling and yelling at me until I did. Then this year in May and July.

#MasksWork I sat there being treated in a hallway chair for 12 hours among people with “summer colds” and weird G.I. issues, and I didn’t catch anything from any of them thankfully.

@augieray I know you have useful points to make about COVID here, but personally "crowded concerts, conferences, classrooms, and bars" fill me with dread and a need to find somewhere quieter quickly. That is me, not them, obvs, but goodness, I can't abide noisy or crowded these days. Probs not a bad thing.

@bytebro I'm with you, but I'm trying to influence others' behaviors and not just the people already cautious.

@augieray I don’t know, I don’t really believe this. (Yes I understand viral load, I don’t believe “uncrowded public spaces” are safe at all. To me it doesn’t matter if the store is on crowded if there was somebody in there five minutes before I went in spewing Covid all over the place. It lingers in the air, I don’t think uncrowded saves me at all & I can’t wrap my head around the mentality of needing your whole face out at the store so badly it’s worth the risk.

Wouldn’t it make sense to save whatever exposure you are willing to risk for something that’s actually worth it? I wear a mask when I visit my friends in their home, but that’s when I would take it off if I was going to take it off, not in a grocery store full of gross strangers. I don’t owe them “smiles”.

@maggiemaybe I generally agree with you, but since almost no one is listening, I try to give advice that people will take. Tell people they need to mask everywhere, and they tune out. I'd rather help people to understand and minimize risks in a way they'll accept.

@augieray @maggiemaybe there's only one way to get people to understand what this virus really is, and that's by not compromising on the truth, imo. If they accept a watered down version of the truth so that they mask sometimes, but go on to misunderstand the actual threat, their watered down approach is susceptible to fall apart in line with that misunderstanding

@currentbias @augieray yeah my previous best friend got Covid for the first time in August 2021 because she thought it was safe she just run into the grocery store without a mask since she was vaccinated. I was glad I didn’t fall for that, it’s a shame she got infected in the few short months it took for the CDC to admit that the shots don’t actually prevent infection.

@maggiemaybe @augieray yep, and I know of people who "always mask indoors" but then take off their mask to eat a sandwich, not realizing they are inhaling (and exhaling) aerosols while doing that, because exceptions for eating and drinking were built into mask mandates

The virus is an opportunist, and requires a proportional level of vigilance. Half measures are its best friend

@augieray yeah I get that, I just can’t apply that to my own life because I care about my own health. And I don’t understand people who don’t.

Last time I went to hang out with my friend I told her I would be wearing a mask in her apartment and not to take it personally because I do that all the time when I’m inside. I sat there and had a lovely visit with her and a couple other people. A couple days later she called me to tell me she just tested positive for strep throat and she wanted me to know, I wasn’t worried because I wore a KN 95 the whole time. I would rather be safe than sorry.

@augieray

You could go ahead and flag that this study also relies on really unethical treatment of incarcerated humans (about which one of the authors is gleefully pleased in a news story about the article), if you're going to insist on citing it.

Uncool to just go around talking about how great it is that you can control people's bodies and force them to get sick.

Especially as someone doing public health or medical research--harm should be treated as though it's grave because it IS--and it should be actively avoided and prevented, not celebrated.

Ghoulish.

@augieray

Americans in this thread may find this feed useful or interesting.

Each Friday the total number of Americans killed by Covid 19 is updated.

Each Friday the number of Americans killed in the last week by Covid 19 is posted.

mastodon.social/@WeeklyAmerica