Upgraded to Sequoia today, so far everything seems to work just fine including my VM which is key.
iPhone mirroring also seems to work with VoiceOver, though AppleVis says it doesn't. Perhaps this was rectified in 15.1 though.
@FreakyFwoof Yep, I upgraded my music machine as well. Phone mirroring was fixed in 15.1, though not completely, as you will soon find out. It’s workable though.