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Mastodon: AboutGet the appKeyboard shortcutsView source codev4.4.0-nightly.2025-04-15

#prion

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Ally Miller

‘Don’t call it zombie deer disease’: scientists warn of ‘global crisis’ as infections spread across the US theguardian.com/environment/20 Another #Prion disease. Other prions have caused disease in cannibalism, and crossed between species where affected individuals are fed to other animals. Affected deer will be in the human food-chain.

The Guardian · ‘Don’t call it zombie deer disease’: scientists warn of ‘global crisis’ as infections spread across the USBy Todd Wilkinson
Public
SUD Recherche ⏚ INRAE

Alerte commune du Comité d’Ethique (CCNE) par nos syndicats SUD Recherche et Education suite à l’interprétation détournée par le #MESR de l’avis de novembre 23 concernant le dossier #prion

Comment expliquer l'enlisement progressif depuis 5 années de ce dossier douloureux par la direction du ministère , sans y voir une conséquence d'un conflit d'intérêt doublé d'un déni de responsabilité ?

sud-recherche.org/SPIPprod/spi

l'affichette résume le texte adressé au CCNE ce 19 mars en ciblant le refus du MESR de mené tout recensement en prenant appui sur une interprétation détournée de l'éclairage éthique donné par le Comité en 2023. A droite une illustration avec le panneau danger risque biologique en référence au prion infectieux .
#veilleESR
Public
SUD Recherche ⏚ INRAE

Nouvelle relance de la DG #INRAE sur l'enlisement du dossier #prion infectieux : nous attendons toujours des réponses aux questions de prévention portées en F3SCT de novembre dernier...

Avent d'exercer notre devoir d'alerte auprès du Comité Consultatif National d'Ethique (CCNE), pour dénoncer l'interprétation détournée du #MESR de l'avis sur le suivi des agents ayant travaillé dans les équipes concernées depuis le début des années 2000.

sud-recherche.org/SPIPprod/spi

Affichette copie du texte en lien ci-dessus sur le site du syndicat.
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Sam

@Shanmonster

Prediction: As the mis-folded protein (prion) contamination spreads, it is inevitable that it will contaminate lands used to graze Bison, Cows, Sheep, Goats, Pigs and Boar.

In time (not all that much time) all of these will cease being foodstuffs in the United States.

In decades ahead this implies that Beef, Lamb, Pork and Goat, along with Bison, Deer, Elk, and other cervids will cease being food in North America, and Scandinavia.

Let that sink in.

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Sam

@Shanmonster

Extent of Chronic Waisting disease updated to February 10, 2025 in North America.

usgs.gov/centers/nwhc/science/

Save the data & graphics before they disappear.

CWD is now in 35 States, 4 Canadian Provinces, Norway, Sweden and Finland. And in captive cervids in most of those, plus Quebec and South Korea.

The major transmission route is fecal-oral. I.e. fecal contaminated land. And once contaminated the land can transmit the disease for 1,000+ years.

Distribution of Chronic Wasting Disease in North America, in Relation to Tribal Lands in the Conterminous United States February 10, 2025
Distribution of Chronic Wasting Disease in North America (Updated) February 10, 2025
Public
Giuseppe Michieli

#Norwegian #moose #CWD induces clinical #disease and #neuroinvasion in gene-targeted mice expressing cervid S138N #prion #protein journals.plos.org/plospathogen

Our study indicates that neuroinvasion of Norwegian moose prions can occur without, or only very limited, replication in the spleen, an unprecedented finding for CWD.

journals.plos.orgNorwegian moose CWD induces clinical disease and neuroinvasion in gene-targeted mice expressing cervid S138N prion proteinAuthor summary Chronic wasting disease (CWD) is a prion disease of cervids that is expanding its global footprint. The pathogenesis of prion disease is driven by the accumulation of PrPSc, a misfolded isoform of the cellular prion protein (PrPC). CWD prion strains from North America are lymphotropic, while Norwegian moose and red deer prions are not, and therefore considered non-contagious, sporadic CWD forms. We studied the propagation of Norwegian CWD prions in gene-targeted mice carrying cervid PrPC variants. We reveal that the Norwegian moose isolate induces clinical disease in mice expressing a PrPC variant previously shown to only display subclinical infection upon challenge with North American CWD. We report the first instance of red deer CWD transmission exclusively to mice overexpressing elk PrPC. Notably, our findings suggest a neuroinvasion route for Norwegian moose CWD prions that potentially bypasses spleen replication, underscoring the complexity of prion disease transmission, and the need for continued research into the behavior of prions across different species and protein variants.
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