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#PopulationGenomics

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Really had to read this article for my current project:

Raynaud et al. 2023 “Performance and limitations of linkage-disequilibrium-based methods for inferring the genomic landscape of recombination and detecting hotspots: a simulation study”

peercommunityjournal.org/artic

peercommunityjournal.orgPerformance and limitations of linkage-disequilibrium-based methods for inferring the genomic landscape of recombination and detecting hotspots: a simulation study

#PopulationGenomics #Biostatistics

I innocently asked why we apply this specific Hardy-Weinberg p-value cutoff as a prefilter step on a whole genome sequencing dataset (prior to population analyses), and now after reading several papers I am still totally unsure of the recommended procedure... I guess I should simply choose a very (very) low cutoff to minimize the number of false positives and just move on.

What's your method?

Ariano, B., Mattiangeli, V., Breslin, E. M., Parkinson, E. W., McLaughlin, R., Thompson, J. E., Power, R. K., Stock, J. T., Mercieca-Spiteri, B., Stoddart, S., Malone, C., Gopalakrishnan, S., Cassidy, L. M., & Bradley, D. G. (2022). Ancient Maltese genomes and the genetic geography of Neolithic Europe. Current Biology, 32(12), 2668-2680.e6. doi.org/10.1016/j.cub.2022.04. #OpenAccess #OA #Journal #Article #Science #Biology #AncientDNA #Ancient #DNA #PopulationGenomics #Europe #Population #Genomics #Archaeology #Archaeodons #Neolithic #European #Migration #Academia #Academic #Academics @science @archaeodons

A great way to kickstart my #Mastodon migration from #twitter With a Preprint 🚨
Led by @Georgette_F from her bachelor 🤯 thesis at @lcgunam. She generated 130+ years old and modern whole-genomes of the (previously) endangered Seychelles paradise flycatcher. We used #PopulationGenomics , demographic reconstructions and fwd simulations to study their genetic load and adaptive potential over time. We ask how this species avoided #extinction and recovered. Brief 🧵 1/7 biorxiv.org/content/10.1101/20

A lot of software can provide genotype likelihood for a #WGS #NGS sample, only one I know provide the likelihood of ALL 10 genotypes for a site, i.e. ANGSD.

Anyone knows any software that calculate all allele likelihood for a site? So I wanna know the probability of observing allele A, C, G, and T in a site. The ones I found only provide probability of one allele (consensus/random).

#Genomics #genomic #PopulationGenomics #bioinformatic #compBio

:boost_ok: :boost_requested: :mastoread: