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#rgc

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The vOICe vision BCI 🧠🇪🇺

Electrically-evoked responses for retinal prostheses are differentially altered depending on ganglion cell types in outer retinal neurodegeneration caused by Crb1 gene mutation frontiersin.org/articles/10.33 #RP #AMD #RGC, retinal implant

FrontiersElectrically-evoked responses for retinal prostheses are differentially altered depending on ganglion cell types in outer retinal neurodegeneration caused by Crb1 gene mutationBackgroundMicroelectronic prostheses for artificial vision stimulate neurons surviving outer retinal neurodegeneration such as retinitis pigmentosa (RP). Yet, the quality of prosthetic vision substantially varies across subjects, maybe due to different levels of retinal degeneration and/or distinct genotypes. Although the RP genotypes are remarkably diverse, prosthetic studies have primarily used retinal degeneration (rd) 1 and 10 mice, which both have Pde6b gene mutation. Here, we report the electric responses arising in retinal ganglion cells (RGCs) of the rd8 mouse model which has Crb1 mutation.MethodsWe first investigated age-dependent histological changes of wild-type (wt), rd8, and rd10 mice retinas by H&E staining. Then, we used cell-attached patch clamping to record spiking responses of ON, OFF and direction selective (DS) types of RGCs to a 4-ms-long electric pulse. The electric responses of rd8 RGCs were analyzed in comparison with those of wt RGCs in terms of individual RGC spiking patterns, populational characteristics, and spiking consistency across trials.ResultsIn the histological examination, the rd8 mice showed partial retinal foldings, but the outer nuclear layer thicknesses remained comparable to those of the wt mice, indicating the early-stage of RP. Although spiking patterns of each RGC type seemed similar to those of the wt retinas, correlation levels between electric vs. light response features were different across the two mouse models. For example,...
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The vOICe vision BCI 🧠🇪🇺

High spatial resolution artificial vision inferred from the spiking output of retinal ganglion cells stimulated by optogenetic and electrical means (in mice) frontiersin.org/articles/10.33 #RGC #optogenetics #AMD #RP #blindness #neuroscience

FrontiersHigh spatial resolution artificial vision inferred from the spiking output of retinal ganglion cells stimulated by optogenetic and electrical meansWith vision impairment affecting millions of people world-wide, various strategies aiming at vision restoration are being undertaken. Thanks to decades of extensive research, electrical stimulation approaches to vision restoration began to undergo clinical trials. Quite recently, another technique employing optogenetic therapy emerged as a possible alternative. Both artificial vision restoration strategies reported poor spatial resolution so far. In this article, we compared the spatial resolution inferred ex vivo under ideal conditions using a computational model analysis of the retinal ganglion cell (RGC) spiking activity. The RGC spiking was stimulated in epiretinal configuration by either optogenetic or electrical means. RGCs activity was recorded from the ex vivo retina of transgenic late-stage photoreceptor-degenerated mice (rd10) using a high-density Complementary Metal Oxide Semiconductor (CMOS) based microelectrode array. The majority of retinal samples were stimulated by both, optogenetic and electrical stimuli using a spatial grating stimulus. A population-level analysis of the spiking activity of identified RGCs was performed and the spatial resolution achieved through electrical and optogenetic photo-stimulation was inferred using a support vector machine classifier. The best f1 score of the classifier for the electrical stimulation in epiretinal configuration was 86% for 32 micron wide gratings and increased to 100% for 128 microns. For optogenetically activa...
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Miguel Angel Manzano

Reforma de l’#IMV i la #RGC + integració de les dues + reglamentació i finançament adequat de les prestacions socials locals de caràcter econòmic.
#agenda
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RT @sindicdegreuges
🗨️"Cada cop més llars necessiten ajuts per obtenir béns bàsics. Cal redefinir les prestacions existents i configurar un sistema de protecció més ajustat a les necessitats de les persones vulnerables"

La síndica s'ha reunit avui amb el conseller de @dsoc…
twitter.com/sindicdegreuges/st

Continued thread
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Miguel Angel Manzano

D’acord en el traspàs del #IMV. Però no serà prou sense la reforma de la #RGC per ampliar cobertures i intensitats i la mateixa reforma de l’#IMV que elimini alguns colls d’ampolla que fan a les dues prestacions molt difícils de coordinar.
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RT @carlescampuzano
El traspàs del #IngrésMínimVital #IMV, tal i com ja tenen Euskadi i Navarra, és imprescindible per evitar sometre a les famílies mès fràgils a un infern burocràtic. No es …
twitter.com/carlescampuzano/st

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