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#biochemical

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Continued thread

#Transcription of my #speech for #deaf folks - as it wasn't provided on vid.

Hi, everyone. Thank you for showing up with #community #solidarity, to call for a #PermanentCeasefire in support of #Palestinians who are suffering #famine & #genocidal violence under #Israeli occupational forces.

My name is Que & I'm a survivor of the #USinvasion #WarOnVietnam. I was a #WarChild conceived & born under active shelling & had #IntergenerationalTrauma pre & post birth.

We were #displaced from our homes & survived in a #RefugeeCamp in Indonesia for a year. We were sponsored to come to Canada in late 1979 as #WarRefugees, seeking #asylum.

My patriarch family lived in #Cholon the #Chinese District in #Saigon & my matriarch family lived in a tiny village near Can Tho near the Hau River in #SouthVietnam. Both sides of my family had already lived through multiple foreign invasions & foreign militarized imperialism & colonialism by the time the US invaded & occupied our lands.

Many of us living Vietnam war civilian survivors can relate so well to the many struggles, the suffering, the violent foreign occupation & also the passionate resilience & resistance of the Palestinian peoples.

Throughout the 1960s into the 1970s both areas that my family lived in were carpet bombed. My Matriarch family village was bombed out of existence by 1970. The rebuilding took 18 years. Cholon was #CarpetBombed twice & the scenes from those aftermaths are eerily similar to the scenes from #Gaza after #Israel carpet bombed the area.

The #USmilitary used #Vietnamese #civilians as involuntary guinea pigs. They tested out never used before #WarMunitions including #biochemical warfare like #AgentOrange & #NerveGasBombs on our peoples.

Our peoples, our lands, our waters - still suffer the toxic & deadly effects from the illegal - illegal #biowarfare chemical uses by the #USA to this day & our peoples & especially our children are still suffering from the many leftover war munitions, exploding, maiming & killing innocent civilians.

Israel is treating the Palestinian peoples very much like the USA had treated our Vietnamese peoples. Like we are not human. We do not deserve to live. The dehumanization of Palestinians is too similar to how the USA dehumanized our Vietnamese peoples. We're savages. We are vermin. We're stupid tunnel rats. We're gooks & we deserve to die.

The USA bombed our #schools, our #hospitals, our #temples, our #ResidentialAreas - just like Israel has bombed schools, hospitals, temples & residential areas in Palestine. The USA has more powerful weapons of mass destruction while fighting resistance forces with much less firepower. The Vietnamese #ResistanceForces also used #TunnelSystems & some of them are now part of an #educational #LivingMuseum.

Vietnam is now #SovereignNation because the occupational militarized US forces left which opened up our path to #DiplomaticNegotiations. Palestinians deserve their true path to diplomatic Solutions too. They deserve a sovereign state. That can not happen without a permanent - not a temporary - a permanent ceasefire - an end to #IllegalOccupation by Israel.

You cannot occupy & oppress a people & claim you are a #democracy. True #Democratic states do not occupy & oppress people for decades. True Democratic states do not jail, murder & deny #PressFreedom to #journalists. True democratic states do not arrest, vilify, nor illegally detain their own citizens with dissenting voices. True democratic states don't continue to violate multiple #InternationalLaws so openly & so disrespectfully.

Israel has become too #arrogant that's mainly due to the Western powers like the USA & #Canada continuing to put their #WarProfiteer interests over #humanitarian & global #PublicInterests.

At a time when we need an arms embargo on Israel, the US & Canada sent billions more in war munitions & funding to Israel. It is shameful.

Our politicians tell us there's not enough money to fund more essential health & medical service needs. There's not enough money to increase the pay scale of essential medical staff. There's not enough money to fund environmental protection & cleanups. There's not enough to help our seniors & disabled not live in poverty anxiety. There's not enough to fund safer, more inclusive, accessible education. There's not enough to provide more low income & some more support of housing for our most marginalized citizens. These are all citizen needs that our governments have told they cannot afford to fully fund but they can find billions to fund ethnic cleansing of the Palestinians. That is not okay & that is not in our public interest.

I urge everyone here to please keep contacting all of your local provincial & federal representatives in every way possible & ask them to please push Trudeau to call for both a permanent ceasefire & to initiate an arms embargo on Israel - NOW.

Please keep having the conversations with people you know & people you don't know about Palestine. The conversations are important. Please keep standing in solidarity with Gaza & all Palestinians.

The antidote to despair is action. This here is humanity in action & I thank all of you for showing your humanity & your ongoing support of Palestinians because remember, no democracy can exist without the freedom of citizens dissenting voices and I appreciate all of your voices dissenting, against our government who is still supporting genocide.

Free Palestine!

"We find that synthesis constitutes a bottleneck for metabolic expansion, which can be alleviated by non-autocatalytic phosphoryl coupling agents. Early phases of the expansion are enriched with that are metal dependent and structurally symmetric, supporting models of early . This expansion trajectory suggests distinct hypotheses regarding the tempo, mode and timing of metabolic pathway evolution"

nature.com/articles/s41559-024

NaturePrimitive purine biosynthesis connects ancient geochemistry to modern metabolism - Nature Ecology & EvolutionConstructing a biosphere-scale model of the evolutionary history of metabolism based on >12,000 biochemical reactions, the authors show that a bottleneck in purine synthesis prevents metabolic expansion from geochemical precursors.

The alphabet contains just four letters, referring to the four , the building blocks that comprise all . Scientists have long wondered whether it’s possible to add more letters to this alphabet by creating brand-new nucleotides in the lab

sflorg.com/2023/12/phar1213230

www.sflorg.comEnzymes Can’t Tell Artificial DNA From the Real ThingUC San Diego researchers are exploring how to add letters to the genetic alphabet to make never-before-seen proteins

:
Work meeting of the LiC Advisory Board members E. Wille & P. Goelitz with Mathias Grote (left) 2021 in Schwabing (Munich). The “Life with Light and Color—A Conversation” by Dieter Oesterhelt (1940-2022) is unique: it is in a large interview with expert Grote and explains the legacy of the late discoverer of the proton pump —a precursor of .
l-i-c.org/1128

new citation:

`Using salt tolerance compartmentalized self-replication (stCSR) and a platform, we obtained 11 mutant sites with enhanced salt tolerance attributes. and analyses revealed that the substitution of conserved amino acids such as G197D, Y369E, T372N, and I378R plays a critical role in maintaining the of exonuclease-deficient under high salt conditions.`

frontiersin.org/articles/10.33

FrontiersUnraveling the salt tolerance of Phi29 DNA polymerase using compartmentalized self-replication and microfluidics platformIn Phi29-α–hemolysin (α-HL) nanopore sequencing systems, a strong electrochemical signal is dependent on a high concentration of salt. However, high salt concentrations adversely affect polymerase activity. Sequencing by synthesis (SBS) requires the use of phi29 polymerase without exonuclease activity to prevent the degradation of modified nucleotide tags; however, the lack of exonuclease activity also affects polymerase processivity. This study aimed to optimize phi29 polymerase for improved salt tolerance and processivity while maintaining its lack of exonuclease activity to meet the requirements of nanopore sequencing. Using salt tolerance compartmentalized self-replication (stCSR) and a microfluidic platform, we obtained 11 mutant sites with enhanced salt tolerance attributes. Sequencing and biochemical analyses revealed that the substitution of conserved amino acids such as G197D, Y369E, T372N, and I378R plays a critical role in maintaining the processivity of exonuclease-deficient phi29 polymerase under high salt conditions. Furthermore, Y369E and T372N have been identified as important determinants of DNA polymerase binding affinity. This study provides insights into optimizing polymerase processability under high-salt conditions for real-time polymerase nanopore sequencing, paving the way for improved performance and applications in nanopore sequencing technologies.

"Here, we have addressed the roles of Foxp3+CD4+ regulatory T cells (Tregs) in the healthful activities of via immunologic, transcriptomic, histologic, metabolic, and analyses of acute and chronic exercise models in mice. Exercise rapidly induced expansion of the muscle Treg compartment, thereby guarding against overexuberant production of interferon-γ and consequent disruptions, particularly aberrancies."

science.org/doi/10.1126/sciimm

The researchers discovered that liver have a clever way of compensating for the missing . By clustering together and exchanging tiny, protein-wrapped packages called , cells are able to communicate and share the materials needed to multiply, allowing them to proliferate even without .

sflorg.com/2023/10/bio10172301

www.sflorg.comNew Cancer Therapy Target Stops Tumor Cells From Sharing ResourcesWhen times are tough, liver cells come together and share molecules needed to multiply; cancer cells may also do this to resist treatment

"Here, we established a method to screen novel target for histidine , using protein fractionation combined with the quantification of by LC-MS/MS. Interestingly, the differential distribution pattern of Nτ-methylated proteins was found between the brain and skeletal , and identified γ-enolase where the His-190 at the Nτ position is methylated in mouse ."

academic.oup.com/jb/article-ab

OUP Academicγ-enolase (ENO2) is methylated at the Nτ position of His-190 among enolase isozymesAbstract. Protein methylation is mainly observed in lysine, arginine and histidine residues. Histidine methylation occurs at one of two different nitrogen atoms